https://www.jonahpropp.com/journal-flores daily 0.75 2025-04-23 https://www.jonahpropp.com/journal-flores/2017/1/4/nunc-et-iaculis-est-c66jk monthly 0.5 2017-02-09 https://www.jonahpropp.com/journal-flores/2017/4/10/in-season-zwszn monthly 0.5 2017-02-09 https://www.jonahpropp.com/journal-flores/2016/9/12/genius-of-love-s8bd6 monthly 0.5 2017-02-09 https://www.jonahpropp.com/journal-flores/2016/9/19/new-workshop-ltmpr monthly 0.5 2017-02-09 https://www.jonahpropp.com/journal-flores/tag/Winter monthly 0.5 https://www.jonahpropp.com/journal-flores/tag/Fall monthly 0.5 https://www.jonahpropp.com/journal-flores/tag/Seasonal monthly 0.5 https://www.jonahpropp.com/journal-flores/tag/Spring monthly 0.5 https://www.jonahpropp.com/gallery-flores daily 0.75 2025-04-23 https://images.squarespace-cdn.com/content/v1/57c71bf09de4bb8daeadcbb3/1483643598377-UKVPZZ6SXG514X22S4HB/Florist0239.jpg Gallery https://images.squarespace-cdn.com/content/v1/57c71bf09de4bb8daeadcbb3/1483643598377-UKVPZZ6SXG514X22S4HB/Florist0239.jpg Gallery https://images.squarespace-cdn.com/content/v1/57c71bf09de4bb8daeadcbb3/1491934172394-806KW6DZ5NBANAHN1JB8/Florist0322.jpg Gallery https://images.squarespace-cdn.com/content/v1/57c71bf09de4bb8daeadcbb3/1483643501205-7Y3EBLGQ0L1LBU8FX24W/Florist0213-crop-4-3-v2.jpg Gallery https://images.squarespace-cdn.com/content/v1/57c71bf09de4bb8daeadcbb3/1491934078254-9ADRJZ3C7W3GF9FRA8SA/Florist0487.jpg Gallery https://www.jonahpropp.com/compositions daily 0.75 2020-03-17 https://www.jonahpropp.com/scores daily 0.75 2019-10-19 https://www.jonahpropp.com/home daily 1.0 2024-01-14 https://images.squarespace-cdn.com/content/v1/5cdc558f673acb0001f39ff1/40973e9e-62a1-4172-b18e-f6f773de4f45/IMG_4187.jpg Home - Jonah Propp Drug Hunter, Musician, Composer https://www.jonahpropp.com/about daily 0.75 2023-10-10 https://images.squarespace-cdn.com/content/v1/5cdc558f673acb0001f39ff1/1559791943903-WHCALDIIOOSYJIISD7IA/image-asset.jpeg About https://images.squarespace-cdn.com/content/v1/57c71bf09de4bb8daeadcbb3/1474057359310-MIYBU29KCPYQVNM8QBPH/test-2.png About https://www.jonahpropp.com/recital daily 0.75 2019-06-30 https://images.squarespace-cdn.com/content/v1/5cdc558f673acb0001f39ff1/1560372939572-07AK5AVT5IU5RPWR0DYV/resized+programe+note.jpg Recital https://www.jonahpropp.com/drug-discovery daily 0.75 2025-10-08 https://images.squarespace-cdn.com/content/v1/5cdc558f673acb0001f39ff1/14894c74-fc91-4e1b-9a6b-a45866a344d9/chem202301621-gra-0001.png Drug Discovery https://images.squarespace-cdn.com/content/v1/5cdc558f673acb0001f39ff1/10f83a8b-636a-40eb-ae2d-fe655ce98e44/space+dI-Stylized3.jpg Drug Discovery - REAL Space for novel antibitoic discovery In an era of escalating antibiotic resistance, there is a pressing need for innovative strategies to develop novel antibiotics. Gram-negative bacteria, characterized by their robust dual-membrane, are intrinsically resistant to a wide range of antibiotics and can readily develop new resistances. Members of this bacterial class comprise numerous pathogenic organisms, including the primary cause of gastric cancer, Helicobacter pylori. In this study, we used the Giga-sized collection of theoretical molecules inside Enamine’s REAL Space to identify inhibitors for H. pylori glutamate racemase. These compounds displayed a diverse range of activity in preventing H. pylori growth, with our most potent hits capable of selective full growth inhibition for metronidazole and clarithromycin resistant H. pylori strains. Alongside the introduction of a novel antibiotic class for this carcinogenic pathogen, our unique implementation of REAL Space holds great promise for Gram-negative antibiotic development as a whole. https://images.squarespace-cdn.com/content/v1/5cdc558f673acb0001f39ff1/c14e6748-98cd-40e4-aaf9-dc5702504e97/42004_2021_605_Fig1_HTML.jpeg Drug Discovery - Decrypting a cryptic allosteric pocket in H. pylori glutamate racemase